Brull, David and Dhamrait, Sukhbir and Myerson, Saul and Erdmann, Jeanette and Regitz-Zagrosek, Vera and World, Mike and Pennell, Dudley and Humphries, Steve E. and Montgomery, Hugh (2001) Bradykinin B2BKR receptor polymorphism and left-ventricular growth response. LANCET, 358 (9288). pp. 1155-1156. ISSN 0140-6736
Full text not available from this repository. (Request a copy)Abstract
Angiotensin-converting-enzyme (ACE) activity regulates left-ventricular growth. The deletion (D), rather than the insertion (I), ACE gene variant is associated with Increased ACE activity and kinin degradation, and the absence (-) rather than the presence (+) of a 9 bp deletion in the gene encoding the bradykinin 2 receptor (B2BKR) Is associated with greater gene expression. We determined the ACE and B2BKR genotype of 109 male army recruits, and measured their physiological left-ventricular growth response to a 10-week physical training programme. Mean left-ventricular growth was 15.7 g (SE 3.5) in those with ACE genotype D/D and B2BKR genotype +9/+9, but -1.37 g (4.1) in those with ACE genotype I/I and B2BKR genotype -9/-9 (p = 0.003 for trend across genotypes). These results suggest that kinins regulate left-ventricular growth, mediating some of the effects of ACE in this regard.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANGIOTENSIN-CONVERTING ENZYME; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Dec 2021 07:27 |
| Last Modified: | 06 Dec 2021 07:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41040 |
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