Schmitz, Gerd and Langmann, Thomas and Heimerl, Susanne (2001) Role of ABCG1 and other ABCG family members in lipid metabolism. JOURNAL OF LIPID RESEARCH, 42 (10). pp. 1513-1520. ISSN 0022-2275
Full text not available from this repository.Abstract
The molecular cloning and identification of mutations in ATP-binding cassette transporters in hereditary diseases have greatly expanded our knowledge of the normal physiology of intracellular lipid transport processes. In addition to the well-known ATP-binding cassette transporter A1 (ABCA1) molecule, ABC transporters belonging to the ABCG (NVhite) subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be critically involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1, the product of a sterol-induced gene, participates in cholesterol and phospholipid efflux. The ABCG5 and ABCG8 transporters, defective in beta -sitosterolemia, are also now considered interesting targets in the control and influence of total body sterol homeostasis. In this review, advances referring to the regulation and function of ABCG half-size transporters are summarized and discussed. In addition, new implications for the transcriptional control, as well as the intracellular routing and localization, of these proteins are presented.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DROSOPHILA WHITE GENE; CHROMOSOME 21Q22.3; HUMAN HOMOLOG; DIETARY-CHOLESTEROL; MOLECULAR-CLONING; HALF-TRANSPORTER; PROTEIN COMPLEX; PLASMA-MEMBRANE; SITOSTEROLEMIA; BINDING; adaptor proteins; Drosophila ABC transporters; gene regulation; macrophage; beta-sitosterolemia; vesicular transport |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 May 2021 06:58 |
| Last Modified: | 18 May 2021 06:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41065 |
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