Renner, Kerstin and Hellerbrand, Sonja and Hermann, Fabian and Riedhammer, Christine and Talke, Yvonne and Schiechl, Gabriela and Gomez, Manuel Rodriguez and Kutzi, Simone and Halbritter, Dagmar and Goebel, Nicole and Bruehl, Hilke and Weissert, Robert and Mack, Matthias (2016) IL-3 promotes the development of experimental autoimmune encephalitis. JCI INSIGHT, 1 (16): e87157. ISSN 2379-3708,
Full text not available from this repository. (Request a copy)Abstract
Little is known about the role of IL-3 in multiple sclerosis (MS) in humans and in experimental autoimmune encephalomyelitis (EAE). Using myelin oligodendrocyte glycoprotein (MOG) peptide-induced EAE, we show that CD4(+) T cells are the main source of IL-3 and that cerebral IL-3 expression correlates with the influx of T cells into the brain. Blockade of IL-3 with monoclonal antibodies, analysis of IL-3 deficient mice, and adoptive transfer of leukocytes demonstrate that IL-3 plays an important role for development of clinical symptoms of EAE, for migration of leukocytes into the brain, and for cerebral expression of adhesion molecules and chemokines. In contrast, injection of recombinant IL-3 exacerbates EAE symptoms and cerebral inflammation. In patients with relapsing-remitting MS (RRMS), IL-3 expression by T cells is markedly upregulated during episodes of relapse. Our data indicate that IL-3 plays an important role in EAE and may represent a new target for treatment of MS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; COLONY-STIMULATING FACTOR; CYTOKINE GM-CSF; HUMAN ENDOTHELIAL-CELLS; MULTIPLE-SCLEROSIS; TRANSGENIC MICE; THERAPEUTIC TARGET; LEUKOCYTE ADHESION; MONONUCLEAR-CELLS; HUMAN BASOPHILS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2019 08:46 |
| Last Modified: | 08 Apr 2019 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4108 |
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