Zorn, Chiara and Gnad, Frieder and Salmen, Sunnhild and Herpin, Timothy and Reiser, Oliver (2001) Deprotection of N-alloc amines by Pd(0)/DABCO - an efficient method for in situ peptide coupling of labile amino acids. TETRAHEDRON LETTERS, 42 (40). pp. 7049-7053. ISSN 0040-4039
Full text not available from this repository. (Request a copy)Abstract
A highly, efficient one-pot deprotection peptide coupling protocol of N-Alloc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times (10 20 min) and allowing the coupling of amino acids that are unstable in unprotected forms. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIKETOPIPERAZINE FORMATION; BETA-AMINO; REDUCTIVE DEPROTECTION; PROTECTING GROUPS; ALPHA-AMINO; ALLYL GROUP; TRANSPROTECTION; SUPPRESSION; DIPEPTIDES; ANALOGS; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Dec 2021 06:44 |
| Last Modified: | 07 Dec 2021 06:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41082 |
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