Ullrich, Heidrun and Jakob, Wolfgang and Froehlich, Dieter and Rothe, Gregor and Prasser, Christopher and Drobnik, Wolfgang and Taeger, Kai and Meier-Hellmann, Andreas and Reinhart, Konrad and Zimmermann, Michael and Schmitz, Gerd (2001) A new endotoxin adsorber: First clinical application. THERAPEUTIC APHERESIS, 5 (5). pp. 326-334. ISSN 1091-6660
Full text not available from this repository. (Request a copy)Abstract
In an open, uncontrolled pilot study, 5 men and 1 woman with suspected gram-negative sepsis were treated with a new whole-blood endotoxin adsorption system. Lipopolysaccharide (LPS) adsorption was carried out by hemoperfusion over high-affinity polymethacrylate-bound albumin (Fresenius Endotoxin Adsorber EN 500). All patients suffered from endotoxemia (>20 pg/ml LAL) and met at least two systemic inflammatory response syndrome (SIRS) criteria. Four patients suffered from pneumonia due to mechanical ventilation, one from peritonitis, and one from pneumonia and peritonitis. Endotoxin adsorption was very well tolerated, and efficient LPS removal was shown in all patients. Apache 11 score immediately before immunoadsorption was 23.5 and was 22.3 after the last treatment. All 6 critically ill patients improved substantially and were discharged from the intensive care unit. LPS whole blood immunoadsorption is a promising new method. No side effects have been observed thus far. A large controlled study to prove clinical efficacy in patients with severe sepsis is under way.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; SEPTIC SHOCK; MONOCLONAL-ANTIBODY; SEPSIS SYNDROME; DOUBLE-BLIND; FAILURE; TRIAL; BINDING; PROTEIN; HA-1A; apheresis treatment; endotoxin; endotoxin adsorber; endotoxin removal; immunoadsorption; sepsis; systemic inflammatory response syndrome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Dec 2021 06:51 |
| Last Modified: | 07 Dec 2021 06:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41083 |
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