Seemayer, C. A. and Distler, O. and Kuchen, S. and Mueller-Ladner, Ulf and Michel, B. A. and Neidhart, M. and Gay, R. E. and Gay, S. (2001) Recent developments in the pathogenesis of rheumatoid arthritis focusing on the role of synovial fibroblasts. ZEITSCHRIFT FUR RHEUMATOLOGIE, 60 (5). pp. 309-318. ISSN 0340-1855, 1435-1250
Full text not available from this repository. (Request a copy)Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is mainly characterized by synovial hyperplasia, pathological immune phenomena and progressive destruction of the affected joints. Various cell types are involved in the pathogenesis of RA including T cells, antigen presenting cells, and endothelial cells. Recent experimental evidence suggests that the CD40/CD154 system might play an important role in the development of RA. Our experimental approach focuses on RA synovial fibroblasts (RA-SF) that are able to destroy articular cartilage independent of inflammation. To elucidate the specific role of those cells in RA pathophysiology the following questions are currently addressed: 1. Which mechanisms do activate the RA-SF? 2. How do the activated RA-SF attach to the cartilage? 3. How do RA-SF destroy cartilage and bone?
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERLEUKIN-1 RECEPTOR ANTAGONIST; MESSENGER-RNA EXPRESSION; TUMOR-SUPPRESSOR GENE; MATRIX METALLOPROTEINASES; DIFFERENTIAL EXPRESSION; BCL-2 EXPRESSION; GROWTH-FACTOR; CATHEPSIN-B; T-CELLS; IN-SITU; rheumatoid arthritis; synovial fibroblasts |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 May 2021 06:45 |
| Last Modified: | 18 May 2021 06:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41089 |
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