Gooch, K. J. and Blunk, Torsten and Courter, D. L. and Sieminski, A. L. and Bursac, P. M. and Vunjak-Novakovic, G. and Freed, L. E. (2001) IGF-I and mechanical environment interact to modulate engineered cartilage development. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 286 (5). pp. 909-915. ISSN 0006-291X
Full text not available from this repository. (Request a copy)Abstract
Bovine calf articular chondrocytes were seeded onto biodegradable polyglycolic acid scaffolds and cultured for four weeks using in vitro systems providing different mechanical environments (static and mixed Petri dishes, static and mixed flasks, and rotating vessels) and different biochemical environments (medium with and without supplemental insulin-like growth factor I, IGF-I). Under all conditions, the resulting engineered tissue histologically resembled cartilage and contained its major constituents: glycosaminoglycans, collagen, and cells. The mechanical environment and supplemental IGF-I (a) independently modulated tissue morphology, growth, biochemical composition, and mechanical properties (equilibrium modulus) of engineered cartilage as previously reported; (b) interacted additively or in some cases nonadditively producing results not suggested by the independent responses, and (c) in combination produced tissue superior to that obtained by modifying these factors individually. (C) 2001 Academic Press.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-I; INTERMITTENT PHYSIOLOGICAL PRESSURE; ARTICULAR CHONDROCYTES; REGENERATING CARTILAGE; PLATE CHONDROCYTES; ELASTIC CARTILAGE; POLYMER SCAFFOLDS; FLUID-FLOW; TISSUE; CELL; tissue engineering; chondrocyte; growth factor; mixing; bioreactors |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Dec 2021 12:40 |
| Last Modified: | 07 Dec 2021 12:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41104 |
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