Zietz, Bettina and Wengler, Irina and Messmann, Helmut and Lock, Guntram and Schoelmerich, Juergen and Straub, Rainer H. (2001) Early shifts of adrenal steroid synthesis before and after relief of short-term cholestasis. JOURNAL OF HEPATOLOGY, 35 (3). pp. 329-337. ISSN 0168-8278, 1600-0641
Full text not available from this repository. (Request a copy)Abstract
Background/Aims: Chronic inflammatory diseases are characterised by a relative reduction of cortisol and adrenal androgens. The time point of appearance of these alterations is not known. Cholestasis may be a model of short-term inflammation to study early alterations of steroidogenesis. Methods: We investigated 18 patients with cholestasis before and after therapeutic abolition of cholestasis (compared to nine control subjects, Co). Results: Serum tumour necrosis factor (TNF) was increased in cholestatic patients as compared to Co (P at least <0.01). Co as compared to cholestatic patients without tumours had elevated levels of plasma adrenocorticotropic hormone (ACTH) and serum dehydroepiandrosterone sulfate (DHEAS) but serum cortisol levels were similar. Levels of ACTH and DHEAS in relation to serum IL-6 or TNF were higher in Co as compared to the cholestatic subgroup without tumours, whereas serum cortisol in relation to these cytokines was similar. In both subgroups of cholestatic patients, we observed the typical inflammation-dependent shift of adrenal hormones into the direction of cortisol in relation to DHEAS. Cholestatic patients with malignant tumours demonstrated an intermediate response pattern. Conclusions: Short-term cholestasis for 5-12 days induced marked alterations of adrenal steroidogenesis which partly resemble the changes observed in chronic inflammatory diseases. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PITUITARY-ADRENOCORTICAL AXIS; RHEUMATOID-ARTHRITIS; DEHYDROEPIANDROSTERONE-SULFATE; BILIARY OBSTRUCTION; SERUM LEVELS; KAPPA-B; INTERLEUKIN-6; STRESS; cholestasis; hypothalamic-pituitary-adrenal axis; adrenocorticotropic hormone; cortisol; dehydroepiandrosterone; steroidogenesis; inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2021 08:09 |
| Last Modified: | 13 Dec 2021 08:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41156 |
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