Schmitz, Gerd and Orso, Evelyn (2001) Intracellular cholesterol and phospholipid trafficking: Comparable mechanisms in macrophages and neuronal cells. NEUROCHEMICAL RESEARCH, 26 (8-9). pp. 1045-1068. ISSN 0364-3190, 1573-6903
Full text not available from this repository. (Request a copy)Abstract
During the past ten years considerable evidences have accumulated that in addition to monocytes/ macrophages, that are implicated in innate immunity and atherogenesis, neuronal cells also exhibit an extensive cellular metabolism. The present study focuses on the major protein players that establish cellular distribution of cholesterol and phospholipids. Evidences are provided that neuronal cells and monocytes/macrophages are equipped with comparable intracellular lipid trafficking mechanisms. Selected examples are presented that trafficking dysfunctions lead to disease development, such as Tangier disease and Niemann-Pick disease type C, or contribute to the pathogenesis of diseases such as Alzheimer disease and atherosclerosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-DENSITY-LIPOPROTEIN; OXYSTEROL-BINDING-PROTEIN; SCAVENGER RECEPTOR-BI; PICK C1 PROTEIN; MONOCYTE-DERIVED MACROPHAGES; STEROL CARRIER PROTEIN-2; APOLIPOPROTEIN-A-I; ACYL-COENZYME-A; MOUSE PERITONEAL-MACROPHAGES; PLECKSTRIN HOMOLOGY DOMAIN; monocytes; macrophages; neuronal cells; membrane traffic; cholesterol; phospholipids |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 May 2021 08:20 |
| Last Modified: | 14 May 2021 08:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41161 |
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