Kammerl, Martin C. and Nuesing, Rolf M. and Seyberth, Hannsjörg W. and Riegger, Guenter A. J. and Kurtz, Armin and Kraemer, Bernhard K. (2001) Inhibition of cyclooxygenase-2 attenuates urinary prostanoid excretion without affecting renal renin expression. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 442 (6). pp. 842-847. ISSN 0031-6768
Full text not available from this repository. (Request a copy)Abstract
This study aimed to assess the impact of cyclooxygenase-2 (COX-2) on the secretion and expression of renin in the kidney cortex. For this purpose renocortical COX-2 expression was moderately stimulated by a low-salt diet or strongly stimulated (increase in mRNA about fivefold) by the combination of a low-salt diet and the angiotensin-I-converting enzyme inhibitor ramipril in male Sprague-Dawley rats. None of these manoeuvres changed medullary COX-2 expression or cortical or medullary COX-1 expression. Treatment with low salt plus ramipril but not with low salt alone led to a three-to fourfold increase of the urinary output of all major prostanoids. The selective COX-2 inhibitor rofecoxib (10 mg/kg per day) markedly lowered basal urinary prostanoid excretion and blunted the stimulation of prostanoid excretion during treatment with low salt plus ramipril. The stimulation of renin secretion by the low-salt diet but not by low salt plus ramipril was attenuated by rofecoxib. The low-salt diet led to a moderate increase of renin gene expression, and additional treatment with ramipril caused a 15-fold increase of renin mRNA. However. no effect of rofecoxib on renin gene expression was observed in any group. These findings suggest that stimulation of COX-2 in the renal cortex leads to the increased formation of all major prostanoids. COX-2-derived prostanoids may play a role in the regulation of renin secretion but not in renin gene expression during the intake of a low-salt diet. However. no major relevance of COX-2-derived prostanoids to renin secretion or renin gene expression during ramipril treatment or a combination of ramipril and a low-salt diet was found.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RENOVASCULAR HYPERTENSION; GENE-EXPRESSION; ANGIOTENSIN-II; MACULA DENSA; RAT-KIDNEY; ACE inhibition; cyclooxygenase 2; kidney; low-salt diet; prostaglandins; rat; renin; rofecoxib |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2021 09:43 |
| Last Modified: | 13 Dec 2021 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41167 |
Actions (login required)
 |
View Item |
