Babel, Nina and Schwarzmann, Fritz and Prang, Nadja and Jaeger, Michael and Wolf, Hans and Kern, Florian and Volk, Hans D. and Reinke, Petra (2001) Association between Epstein-Barr virus infection and late acute transplant rejection in long-term transplant patients. TRANSPLANTATION, 72 (4). pp. 736-739. ISSN 0041-1337
Full text not available from this repository.Abstract
Recently we reported about a possible involvement of extrarenal systemic cytomegalovirus (CMV) infection in graft deteriorating immune processes. We now examined whether Epstein-Barr virus (EBV) may also be associated with late renal graft injury. We analyzed the expression of early antigen., viral capsid antigen-, and a latency-associated EBV-RNA-transcript, which is not translated into protein in peripheral blood mononuclear cells of kidney transplant patients with histologically proven late acute rejection and no signs of CMV or any other infection (A), patients with stable graft function (B), and healthy probands (C). A total of 40% in group A vs. 5 and 0% in groups B and C, respectively, expressed early antigen-mRNA (P <0.05) suggesting an activation of lytic EBV infection. Response to steroid bolus therapy in group A was comparably poor with that observed in CMV-related graft injury. Our data suggest that extrarenal lytic EBV infection may also be involved in the pathogenesis of late graft injury. A controlled ganciclovir trial may prove the significance of our observation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARRIER STATE; T-CELLS; RECIPIENTS; EXPRESSION; BLOOD; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2021 05:41 |
| Last Modified: | 14 Dec 2021 05:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41188 |
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