Janshoff, Andreas and Ross, Michaela and Gerke, Volker and Steinem, Claudia (2001) Visualization of annexin I binding to calcium-induced phosphatidylserine domains. CHEMBIOCHEM, 2 (7-8). 587-+. ISSN 1439-4227
Full text not available from this repository. (Request a copy)Abstract
A monomolecular protein adsorption was observed for the binding of annexin I to phosphatidylserine-enriched lipid domains. The interactions of this membrane-associated protein (red in the picture; green = N terminus, . = Ca(2+)-binding site) with phospholipid bilayers immobilized on mica were visualized by scanning force microscopy. Domain formation in 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/-phosphoserine layers was induced by Ca(2+) ions rather than by the protein itself, as demonstrated by time-of-flight secondary-ion mass spectrometric analysis and lateral force microscopy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ION MASS-SPECTROMETRY; VESICLE AGGREGATION; 3-DIMENSIONAL STRUCTURE; FORCE MICROSCOPY; MUTAGENESIS; MEMBRANES; CRYSTAL; PROTEIN; TOPOGRAPHY; MECHANISM; annexins; mass spectrometry; membrane proteins; phospholipids; scanning probe microscopy |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2021 06:35 |
| Last Modified: | 14 Dec 2021 06:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41197 |
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