Sarras, Michael P. and Deutzmann, Rainer (2001) Hydra and Niccolo Paganini (1782-1840) - two peas in a pod? The molecular basis of extracellular matrix structure in the invertebrate, Hydra. BIOESSAYS, 23 (8). pp. 716-724. ISSN 0265-9247
Full text not available from this repository.Abstract
The body wall of Hydra is organized as an epithelial bilayer with an intervening extracellular matrix (ECM). Molecular and biochemical analyses of Hydra ECM have established that it contains components similar to those seen in more complicated vertebrates such as human. In terms of biophysical parameters, Hydra ECM is highly flexible; a property that facilitates continuous movements along the organism's longitudinal and radial axis. A more rigid ECM, as in vertebrates, would not be compatible with this degree of movement. The flexible nature of Hydra ECM can now be explained in part by the unique structure of the organism's collagens. Interestingly, some aspects of the structural features of Hydra collagens mimic what is seen in Ehlers-Danlos syndrome, an inherited condition in humans that results in an abnormally flexible ECM that can be debilitating in extreme cases. This review will focus on structure-function relationships of the ECM of Hydra. (C) 2001 John Wiley & Sons, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BASEMENT-MEMBRANE; HEAD REGENERATION; LAMININ CHAIN; BASAL LAMINA; IV COLLAGEN; VULGARIS; MESOGLEA; EXPRESSION; NEMATOCYTES; FIBRONECTIN; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Rainer Deutzmann |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 May 2021 08:08 |
| Last Modified: | 14 May 2021 08:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41211 |
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