Bosserhoff, Anja-Katrin and Echtenacher, B. and Hein, R. and Buettner, R. (2001) Functional role of melanoma inhibitory activity in regulating invasion and metastasis of malignant melanoma cells in vivo. MELANOMA RESEARCH, 11 (4). pp. 417-421. ISSN 0960-8931
Full text not available from this repository. (Request a copy)Abstract
MIA (melanoma inhibitory activity) has been previously isolated from the tissue culture supernatant of melanoma cell lines as an autoregulatory activity, inhibiting thymidine incorporation. However, subsequent analyses of melanocytic tumours in vivo have correlated enhanced MIA expression with progression of melanocytic tumours, conflicting with the idea that MIA acts as a tumour suppressor. To investigate the role of MIA in vivo, we have therefore generated a panel of stably transfected B16 cell clones secreting different amounts of MIA. The capacity of these cell clones to form lung metastases in syngeneic C57B16 mice was strictly correlated to the level of MIA secretion, but the clones did not differ with respect to their proliferation in vitro. In summary, we suggest that MIA plays a causal role in promoting the metastasis of malignant melanomas, involving inhibition of tumour cell attachment to extracellular matrix molecules within their local milieu. (C) 2001 Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SERUM MARKER; ACTIVITY MIA; EXPRESSION; PROTEIN; TUMOR; STAGE; LINE; B16 melanoma cell line; melanoma; metastasis; MIA; mouse model |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2021 10:48 |
| Last Modified: | 14 Dec 2021 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41233 |
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