Gruss, Claus J. and von Kobyletzki, Gregor and Behrens-Williams, Stefanie C. and Lininger, John and Reuther, Tilmann and Kerscher, Martina and Altmeyer, Peter (2001) Effects of low dose ultraviolet A-1 phototherapy on morphea. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 17 (4). pp. 149-155. ISSN 0905-4383
Full text not available from this repository. (Request a copy)Abstract
Aim: The effects of low dose ultraviolet A-1 (UVA-1) phototherapy on different clinical stages of morphea (localized scleroderma) were analyzed in this case study, Based on these data, the different types of phototherapy described in the literature and currently used for treatment of morphea are compared. Methods: Three patients with severe plaque type morphea in different stages were studied: one patient with late-stage lesions having stable sclerotic plaques; another patient with active inflammatory lesions; and a third patient with late-stage lesions associated with overlying lichen sclerosus et atrophicus (LSA), The treatment given was low dose UVA-1 phototherapy with single doses of 20 J/cm(2) administered four times a week for 6 weeks, and once a week for another 6 weeks, Results: Following UVA-1 phototherapy, the sclerotic plaques resolved, leaving smooth and soft tanned skin with normal structure, consistency and folding capability, In morphea with overlying LSA the elastic fibers did not completely return to the superficial papillary dermis despite the clinical clearance of both morphea and LSA, These data suggest that low dose UVA-1 phototherapy may improve, but not completely reverse, the histopathological changes of LSA, No side effects were observed during or after treatment. Conclusion: Our observations show in three patients that low-dose UVA-1 phototherapy is highly effective for treatment of all stages of morphea, including early inflammatory and late sclerotic lesions, and morphea with overlying lichen sclerosus et atrophicus, Because of its safety and efficacy, low dose UVA-1 phototherapy appears to be the treatment modality of choice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN DERMAL FIBROBLASTS; LOCALIZED SCLERODERMA; UVA(1) PHOTOTHERAPY; COLLAGENASE MMP-1; THERAPY; RADIATION; lichen sclerosus et atrophicus; localized scleroderma; low dose UVA-1; phototherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2021 13:23 |
| Last Modified: | 14 Dec 2021 13:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41239 |
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