Iwasa, Kinuko and Moriyasu, Masataka and Yamori, Takao and Turuo, Takashi and Lee, Dong-Ung and Wiegrebe, Wolfgang (2001) In vitro cytotoxicity of the protoberberine-type alkaloids. JOURNAL OF NATURAL PRODUCTS, 64 (7). pp. 896-898. ISSN 0163-3864, 1520-6025
Full text not available from this repository. (Request a copy)Abstract
In vitro cytotoxic activities of 24 quaternary protoberberine alkaloids related to berberine have been evaluated using a human cancer cell line panel coupled with a drug sensitivity database. Extending the alkyl chain at position 8 or 13 strongly influenced the cytotoxic activity, that is, relative lipophilicity as well as the size of the substituent affects cytotoxicity. The highest level of activity was observed in 8- or 13-hexyl-substituted derivatives of berberine. Structure - activity relationships are described.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-CELL-LINES; ANTICANCER DRUG SCREEN; PANEL; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Jan 2022 11:49 |
| Last Modified: | 11 Jan 2022 11:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41307 |
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