Fischereder, Michael and Luckow, Bruno and Hocher, Berthold and Wuethrich, Rolf P. and Rothenpieler, Uwe and Schneeberger, Helmut and Panzer, Ulf and Stahl, Rolf A. K. and Hauser, Ingeborg A. and Budde, Klemens and Neumayer, Hans-H. and Kraemer, Bernhard K. and Land, Walter and Schloendorff, Detlef (2001) CC chemokine receptor 5 and renal-transplant survival. LANCET, 357 (9270). pp. 1758-1761. ISSN 0140-6736
Full text not available from this repository. (Request a copy)Abstract
Background About 1% of white populations are homozygous carriers of an allele of the gene for the CC chemokine receptor 5 (CCR5) with a 32 bp deletion (CCR5 Delta 32), which leads to an inactive receptor. During acute and chronic transplant rejection, ligands for CCR5 are upregulated, and the graft is infiltrated by CCR5-positive mononuclear cells. We therefore investigated the influence of CCR5 Delta 32 on renal-transplant survival Methods Genomic DNA from peripheral-blood leucocytes of 1227 renal-transplant recipients was screened by PCR for the presence of CCR5 Delta 32. Demographic and clinical data were extracted from hospital records. Complete follow-up data were available for 576 recipients of first renal transplants. Graft survival was analysed by Fisher's exact test and Kaplan-Meier plots compared with a log-rank test. Findings PCR identified 21 patients homozygous for CCR5 Delta 32 (frequency 1.7%). One patient died with a functioning graft. Only one of the remaining patients lost transplant function during follow-up (median 7.2 years) compared with 78 of the 555 patients with a homozygous wild-type or heterozygous CCR5 Delta 32 genotype. Graft survival was significantly longer in the homozygous CCR5 Delta 32 group than in the control group (log-rank p=0.033; hazard ratio 0.367 [95% CI 0.157-0.859]). Interpretation Patients homozygous for CCR5 Delta 32; show longer survival of renal transplants than those with: other genotypes, suggesting a pathophysiological role for CCR5 in transplant Loss. This receptor may be a useful target for the prevention of transplant loss.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIV-1 INFECTION; FUNCTIONAL EXPRESSION; ALLOGRAFT-REJECTION; MOLECULAR-CLONING; DELETION ALLELE; RANTES; GENE; RESISTANCE; MIP-1-ALPHA; INDIVIDUALS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jan 2022 09:41 |
| Last Modified: | 18 Jan 2022 09:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41351 |
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