May, Arne and Goadsby, Peter J. (2001) Pharmacological opportunities and pitfalls in the therapy of migraine. CURRENT OPINION IN NEUROLOGY, 14 (3). pp. 341-346. ISSN 1350-7540
Full text not available from this repository. (Request a copy)Abstract
The mild vasoconstrictor effects of modern antimigraine drugs, such as serotonin (5-HT; 5-hydroxytryptamine) (1B/D) agonists, have led to a search for nonvasoconstrictor approaches to therapy. Such approaches have included substance P (neurokinin I) antagonists, endothelin antagonists and highly specific 5HT(1D) agonists, All of these substances are effective in animal models and have no significant vasoconstrictive effects. However, all of them failed to demonstrate any antimigraine effects. Current clinical and experimental evidence therefore supports the view that isolated peripheral trigeminal nerve inhibition is insufficient to relieve acute migraine. Curr Opin Neurol 14:341-345. (C) 2001 Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TACHYKININ NK1 RECEPTOR; GENE-RELATED PEPTIDE; NEUROGENIC PLASMA EXTRAVASATION; TRIGEMINAL NUCLEUS CAUDALIS; SUPERIOR SAGITTAL SINUS; RAT DURA-MATER; IMMUNOREACTIVE SUBSTANCE-P; TRIGEMINOVASCULAR SYSTEM; ACETYLSALICYLIC-ACID; EXTRACEREBRAL CIRCULATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jan 2022 13:15 |
| Last Modified: | 18 Jan 2022 13:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41363 |
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