Geisser, Bernd and Koenig, Burkhard and Alsfasser, Ralf (2001) Selective recognition of copper(II) by a water-soluble, emitter-receptor conjugate containing a ruthenium chromophore, a lysine bridge, and a cyclen unit. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (6). pp. 1543-1549. ISSN 1434-1948
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The amino acid derivative [H-Lys(Ru(bipy)(2)m)-cyclenH(2)](PF6)(5) (7; Lys= lysine, bipy= 2,2'-bipyridyl, m = 4-carbonyl-4'-methyl-2,2'-bipyridyl, cyclen = 1,4,7,10-tetraazacyclododecane) has been synthesized. A modular approach was taken which involves only standard amide-coupling methods well-known from peptide synthesis. Compound 7 is readily soluble in water. It contains a luminescent ruthenium chromophore and a cyclen ligand which serves as a binding site for metal ions. The emission of 7 is pH-independent but efficiently quenched by CU2+ ions in a pH range of 6-7. Copper(II) binding is reversible upon protonation of the ligand at pH values below 6. In contrast, no significant spectral changes are observed with Zn2+ and Ni2+, respectively. Thus, 7 selectively recognizes copper(II) in aqueous solution under slightly acidic to neutral conditions. Unfortunately, applications at higher pH values are limited by metal-promoted hydrolysis of 7 under mildly basic conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHOTOINDUCED ELECTRON-TRANSFER; AMINO-ACID; TRANSITION-METALS; FLUORESCENT CHEMOSENSORS; REDOX DERIVATIVES; AQUEOUS-SOLUTION; AROMATIC-GROUPS; CARBON-DIOXIDE; DIVALENT ZINC; NEUTRAL PH; bioinorganic chemistry; amino acids; luminescence; macrocyclic ligands; copper; ruthenium; molecular recognition |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jan 2022 13:40 |
| Last Modified: | 18 Jan 2022 13:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41367 |
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