Kriegmair, Maximilian Christian and Balk, Matthias and Wirtz, Ralph and Steidler, Annette and Weis, Cleo-Aron and Breyer, Johannes and Hartmann, Arndt and Bolenz, Christian and Erben, Philipp (2016) Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer. ANTICANCER RESEARCH, 36 (10). pp. 5205-5213. ISSN 0250-7005, 1791-7530
Full text not available from this repository. (Request a copy)Abstract
Aim: To evaluate the prognostic role of the p53-upstream inhibitors MDM2, MDM4 and its splice variant MDM4-S in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Materials and Methods: mRNA Expression levels of MDM2, MDM4 and MDM4-S were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) in 75 RC samples. Logistic regression analyses identified predictors of recurrence-free (RFS) and cancer-specific survival (CSS). Results: High expression was found in 42% (MDM2), 27% (MDMD4) and 91% (MDM4-S) of tumor specimens. Increased MDM2 expression was significantly associated with higher tumor stage (p=0.05) and lymphovascular invasion (LVI) (p=0.041). In the univariate analysis, low MDM4 expression (hazard ratio (HR)=5.93; p=0.002; HR=3.00; p=0.047), but not MDM2 (HR=1.63; p=0.222; HR=1.59; p=0.27), were associated with RFS and CSS. In the multivariate analysis, the combination of low MDM4 and high MDM2 was significant for RFS and CSS (HR=14.9; p=0.001; HR=5.63; p=0.019). Conclusion: The combination of MDM2 and MDM4 expression is an independent predictor in patients undergoing RC for MIBC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADVANCED UROTHELIAL CANCER; MESSENGER-RNA; AMPLIFICATION TARGET; P53-DEFICIENT CELLS; URINARY-BLADDER; TUMOR-FORMATION; CARCINOMA; THERAPY; SNP309; TP53; bladder cancer; MDM2; HDMX; marker; prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2019 08:51 |
| Last Modified: | 08 Apr 2019 08:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4137 |
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