Seitz, Carola and Mueller, Peter and Krieg, Rene C. and Maennel, Daniela N. and Hehlgans, Thomas (2001) A novel p75TNF receptor isoform mediating NF kappa B activation. JOURNAL OF BIOLOGICAL CHEMISTRY, 276 (22). pp. 19390-19395. ISSN 0021-9258
Full text not available from this repository.Abstract
We report the identification of a novel p75TNF receptor isoform termed icp75TNFR, which is generated by the use of an alternative transcriptional start site within the p75TNFR gene and characterized by regulated intracellular expression. The icp75TNFR protein has an apparent molecular mass of similar to 50 kDa and is recognized by antibodies generated against the transmembrane form of p75TNFR. The icp75TNFR binds the tumor necrosis factor(TNF) and mediates intracellular signaling. Overexpression of the icp75TNFR cDNA results in TNF-induced activation of NF kappaB in a TNF receptor-associated factor 2 (TRAF2)-dependent manner. Thus, our results provide an example for intracellular cytokine receptor activation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; TNF RECEPTOR; FUNCTIONAL-CHARACTERIZATION; MOLECULAR-CLONING; VIRAL-PROTEINS; EXPRESSION; PROLIFERATION; CYTOTOXICITY; FAMILY; CELLS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jan 2022 10:19 |
| Last Modified: | 24 Jan 2022 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41391 |
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