Dosch, Tanja and Horn, Florian and Schneider, Grit and Kraetzer, Friedrich and Dobner, Thomas and Hauber, Joachim and Stauber, Roland H. (2001) The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-Independent mechanism. JOURNAL OF VIROLOGY, 75 (12). pp. 5677-5683. ISSN 0022-538X
Full text not available from this repository. (Request a copy)Abstract
The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viral mRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells, Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen the potential role of E1B-55K as the "driving force" for adenoviral late mRNA export.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LATE GENE-EXPRESSION; NUCLEAR EXPORT SIGNAL; EARLY REGION-4; LIVING CELLS; INTRACELLULAR TRAFFICKING; TUMOR-ANTIGEN; PROTEIN; REV; BINDING; RNA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jan 2022 13:55 |
| Last Modified: | 24 Jan 2022 13:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41399 |
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