Lorbeer, Roberto and Baumeister, Sebastian E. and Doerr, Marcus and Nauck, Matthias and Grotevendt, Anne and Schlesinger, Sabrina and Teumer, Alexander and Voelzke, Henry and Grabe, Hans-Joergen and Wallaschofski, Henri and Vasan, Ramachandran S. and Lieb, Wolfgang (2016) Angiopoietin-2, its Soluble Receptor Tie-2, and Metabolic Syndrome Components in a Population-Based Sample. OBESITY, 24 (10). pp. 2038-2041. ISSN 1930-7381, 1930-739X
Full text not available from this repository. (Request a copy)Abstract
Objective: Since angiopoietin-2 (Ang-2) levels strongly correlate with cardiovascular mortality and subclinical cardiovascular disease, it was hypothesized that levels of Ang-2 and its soluble receptor (sTie-2) were associated with the metabolic syndrome (MetS) and individual MetS components. Methods: Within the population-based Study of Health in Pomerania, two sets of analyses were performed. First, Ang-2 and sTie-2 were related to the prevalence of MetS and its components cross-sectionally (n=3,205). Second, the association between baseline Ang-2 and sTie-2 and incident MetS or longitudinal changes in its components in 1,295 individuals was investigated. Results: High Ang-2 levels (90th percentile), compared with low Ang-2 levels (10th percentile), were positively associated with MetS (OR: 1.78) and with the following MetS criteria: increased triglycerides, lower HDL cholesterol, and higher non-fasting glucose. Furthermore, high sTie-2 levels (90th percentile), compared with low levels (10th percentile), were positively related to MetS (OR: 1.58) and most of its components. However, Ang-2 and sTie-2 levels were not associated with incident MetS or longitudinal change in components of MetS. Conclusions: Ang-2 and sTie-2 levels were cross-sectionally associated with MetS and several of its components. However, Ang-2 and sTie-2 levels were not associated with incident MetS or changes in individual MetS components during follow-up.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUBCLINICAL CARDIOVASCULAR-DISEASE; CIRCULATING ANGIOPOIETIN-2; ENDOTHELIAL FUNCTION; GROWTH-FACTORS; ANGIOGENESIS; INFLAMMATION; ASSOCIATION; HEALTH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2019 11:53 |
| Last Modified: | 08 Apr 2019 11:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4145 |
Actions (login required)
 |
View Item |
