Woertgen, Chris and Rothoerl, Ralf Dirk and Brawanski, Alexander (2001) Neuron-specific enolase serum levels after controlled cortical impact injury in the rat. JOURNAL OF NEUROTRAUMA, 18 (5). pp. 569-573. ISSN 0897-7151
Full text not available from this repository. (Request a copy)Abstract
The aim of this study was to investigate the time course and the correlation of neuron-specific enolase (NSE) serum levels to the severity of traumatic brain injury in rats, Sixty-five male Wistar rats were subjected to severe cortical impact injury (100 PSI, 2 mm deformation). Blood samples were drawn directly after trauma and after 1, 6, 12, 24, and 48 h in the trauma group. In the sham operated levels animals samples were drawn directly after craniotomy and after 6 and 48 h, Additionally, NSE serum levels after controlled cortical impact at different levels of severity samples (45 PSI, 75 PSI; 2 mm deformity) were compared to sham-operated animals, The severity of the injury was not validated histopathologically, NSE serum levels were estimated with a commercially available enzyme immunoassay (LIA mat Sangtec(R)), The control animals showed a NSE serum level of 8.82 mug/L (mean, n = 10) and the injured animals demonstrated a time-dependent release of NSE into the serum. The highest NSE serum values were detected 6 h after trauma (31.5 mug/L mean, n = 10), In addition, we found a close relationship between NSE serum levels and the severity of traumatic brain injury in the cortical impact model. NSE serum levels reflect in a time-dependent manner the severity of brain trauma induced by cortical impact model in rat.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MINOR HEAD-INJURY; ANEURYSMAL SUBARACHNOID HEMORRHAGE; S-100 PROTEIN; BRAIN-DAMAGE; CEREBROSPINAL-FLUID; COMPUTED-TOMOGRAPHY; ISCHEMIC STROKE; SERIAL S-100; BLOOD; INDICATORS; neuron-specific enolase; rat; traumatic brain injury |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2022 06:18 |
| Last Modified: | 01 Feb 2022 06:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41465 |
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