Castrop, Hayo and Schweda, Frank and Schumacher, Karl and Wolf, Konrad and Kurtz, Armin (2001) Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 12 (5). pp. 867-874. ISSN 1046-6673
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This study aimed to assess the role of cyclooxygenase-2 (COX-2)-derived prostanoids for the macula densa control of renal afferent arteriolar resistance and for renin secretion. For this purpose, studied were the effects of blocking macula densa salt transport by the loop diuretic bumetanide (100 muM) on renal perfusate flow and on renin secretion in isolated perfused rats, in which renocortical COX-2 expression was prestimulated in vivo by treatment with the angiotensin-converting enzyme inhibitor ramipril, with low-salt diet, or with a combination of both. These maneuvers stimulated COX-2 expression in an order of ramipril + low salt much greater than low salt > ramipril > controls. Flow rates through isolated kidneys at a constant pressure of 100 mmHg were dependent on the pretreatment regimen, in the way that they went in parallel with COX-2 expression. The COX-2 inhibitor NS-398 (10 muM) lowered flow rates depending on the COX-2 expression level and was most pronounced therefore after pretreatment with low salt + ramipril. NS-398 did not change the increase of flow in response to bumetanide but attenuated the stimulation of renin secretion in response to bumetanide in a manner depending on the expression level of COX-2. These findings suggest that in states of increased renocortical expression of COX-2, overall renal vascular resistance and the macula densa control of renin secretion become dependent on COX-2-derived prostanoids.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAT-KIDNEY; RENOVASCULAR HYPERTENSION; EXPRESSION; INHIBITION; PRESSURE; MECHANISMS; VOLUNTEERS; INCREASES; ISOFORMS; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2022 07:14 |
| Last Modified: | 01 Feb 2022 07:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41467 |
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