Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation

Padovan, C. S. and Gerbitz, A. and Sostak, P. and Holler, E. and Ferrara, J. L. M. and Bise, K. and Straube, A. (2001) Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation. NEUROLOGY, 56 (8). pp. 1106-1108. ISSN 0028-3878

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Abstract

Neurologic manifestation of graft-versus-host, disease (GvHD) after allogeneic bone marrow transplantation (BMT) has until now been limited to rare neuromuscular syndromes. Investigating cerebral findings using a murine BMT model, the authors found parenchymal lymphocytic inflammation, microglia activation, and mild cerebral angiitis-like changes in allogeneic transplanted animals but not in syngeneic controls. These findings suggest that cerebral involvement during GvHD may be a new neurologic complication after BMT.

Item Type: Article
Uncontrolled Keywords: CENTRAL-NERVOUS-SYSTEM; EXPRESSION;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 01 Feb 2022 16:27
Last Modified: 01 Feb 2022 16:27
URI: https://pred.uni-regensburg.de/id/eprint/41490

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