Kees, Frieder and Bucher, M. and Mair, G. and Grobecker, H. (2001) Determination of opipramol in human plasma by high-performance liquid chromatography with photometric detection using a cyanopropyl column. JOURNAL OF CHROMATOGRAPHY B, 753 (2). pp. 337-342. ISSN 0378-4347
Full text not available from this repository. (Request a copy)Abstract
A high-performance liquid chromatographic method is described for the determination of opipramol in human plasma. Opipramol was extracted into tert.-butylmethyl ether, separated on a cyanopropyl silica column and detected at 254 nm. Imipramine was used as internal standard. The limit of quantitation was 250 pg/ml using 1.5 mi plasma. Precision was better than 9%, inaccuracy less than 8%. The assay is more sensitive than previously published methods, and it has been applied to the analysis of plasma samples from a pharmacokinetic study. (C) 2001 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ELECTROCHEMICAL DETECTION; METABOLITES; opipramol |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Feb 2022 12:47 |
| Last Modified: | 02 Feb 2022 12:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41506 |
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