Broll, Karin and Richter, Georg and Pauly, Susanne and Hofstaedter, Ferdinand and Schwarz, Herbert (2001) CD137 expression in tumor vessel walls - High correlation with malignant tumors. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 115 (4). pp. 543-549. ISSN 0002-9173
Full text not available from this repository.Abstract
CD137 (ILA4-1BB), a member of the tumor necrosis factor receptor family, and its ligand are expressed on activated T lymphocytes and on antigen-presenting cells, respectively. Via bidirectional signal transduction, this receptor-ligand system regulates the activation, proliferation, and survival of T and B lymphocytes and monocytes. We used immunohistochemical studies on human tissue samples to determine in vivo CD137 expression in nonimmune tissue samples. Strong CD137 expression was found in blood vessel walls, on the endothelial layer; and on the vascular smooth muscle cells. But in 32 healthy tissue samples examined, none contained CD137-positive vessels. Also, in benign tumors (2/14) and in inflammatory tissues (2/9) only a minority had CD137-expressing vessels. However malignant tumors had a significantly enhanced frequency of CD137-expressing blood vessels (11/34).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-RECEPTOR FAMILY; NECROSIS-FACTOR; HUMAN 4-1BB; ACTIVATION; MEMBER; CELLS; ILA; MACROPHAGES; PROLIFERATION; LYMPHOCYTES; CD137; blood vessel; tumor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Feb 2022 06:06 |
| Last Modified: | 07 Feb 2022 06:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41511 |
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