Haak, Eva and Abletshauser, Claudia and Weber, Sonja and Goedicke, Christine and Martin, Nicole and Hermanns, Notbert and Lackner, Karl and Kusterer, Klaus and Usadel, Klaus Henning and Haak, Thomas (2001) Fluvastatin therapy improves microcirculation in patients with hyperlipidaemia. ATHEROSCLEROSIS, 155 (2). pp. 395-401. ISSN 0021-9150
Full text not available from this repository.Abstract
The purpose of this study was to investigate the effect of fluvastatin on the microcirculation of patients with hyperlipidaemia (low-density lipoprotein cholesterol > 160 mg/dL, triglycerides < 350 mg/dl) inadequately controlled by diet. After a dietary run-in of 4 weeks, patients were randomised in a double-blind study to receive fluvastatin 40 mg twice daily (n = 24) or placebo (n = 24) for 12 weeks. The effect on microcirculation was assessed using capillary microscopy and laser Doppler fluxmetry at the nailfold at baseline and at 6 and 12 weeks after initiation of therapy. Capillaroscopy showed that fluvastatin improved microcirculation, i.e. time to peak flow. during postocclusive reactive hyperaemia dropped from 19.7 <plus/minus> 7.2 s at baseline to 12.3 +/- 9.5 s at week 6 (P < 0.01) and 10.6 <plus/minus> 6.5 s at week 12 (P < 0.0001). These results were confirmed using laser Doppler fluxmetry to study microcirculation in thermoregulatory capillaries at the same site. A significant decrease in total and LDL-cholesterol was achieved during fluvastatin therapy. In conclusion, fluvastatin therapy improves microcirculation in nutritive as well as thermoregulatory capillaries in hypercholesterulaemic patients within 6 weeks. <(c)> 2001 Elsevier Science Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-ARTERY DISEASE; CHOLESTEROL-LOWERING THERAPY; ENDOTHELIUM-DEPENDENT VASODILATION; FOREARM RESISTANCE VESSELS; LOW-DENSITY-LIPOPROTEIN; HYPERCHOLESTEROLEMIC PATIENTS; NITRIC-OXIDE; REACTIVE HYPEREMIA; ATHEROSCLEROSIS; DYSFUNCTION; fluvastatin; microcirculation; hyperlipidaemia; capillaroscopy; laser Doppler imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Feb 2022 06:30 |
| Last Modified: | 07 Feb 2022 06:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41517 |
Actions (login required)
 |
View Item |
