Meidenbauer, Norbert and Andreesen, Reinhard and Mackensen, Andreas (2001) Dendritic cells for specific cancer immunotherapy. BIOLOGICAL CHEMISTRY, 382 (4). pp. 507-520. ISSN 1431-6730
Full text not available from this repository.Abstract
The characterization of tumor-associated antigens recognized by human T lymphocytes in a major histocompatibility complex (MHC)-restricted fashion has opened new possibilities for immunotherapeutic approaches to the treatment of human cancers. Dendritic cells (DC) are professional antigen presenting cells that are well suited to activate T cells toward various antigens, such as tumor-associated antigens, due to their potent costimulatory activity. The availability of large numbers of DC, generated either from hematopoietic progenitor cells or monocytes in vitro or isolated from peripheral blood, has profoundly changed pre-clinical research as well as the clinical evaluation of these cells. Accordingly, appropriately pulsed or transfected DC may be used for vaccination in the field of infectious diseases or tumor immunotherapy to induce antigen-specific T cell responses. These observations led to pilot clinical trials of DC vaccination for patients with cancer in order to investigate the feasibility, safety, as well as the immunologic and clinical effects of this approach. Initial clinical studies of human DC vaccines are generating encouraging preliminary results demonstrating induction of tumor-specific immune responses and tumor regression. Nevertheless, much work is still needed to address several variables that are critical for optimizing this approach and to determine the role of DC-based vaccines in tumor immunotherapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-LYMPHOCYTE RESPONSES; COLONY-STIMULATING FACTOR; ANTIGEN-PRESENTING CELLS; HUMAN PERIPHERAL-BLOOD; HEMATOPOIETIC PROGENITOR CELLS; EXOGENOUS SOLUBLE-ANTIGEN; MEDIATED GENE-TRANSFER; SERUM-FREE CONDITIONS; GENERATED IN-VITRO; C-KIT-LIGAND; antigen presenting cells; T cells; tumor immunotherapy; vaccination |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 May 2021 06:21 |
| Last Modified: | 14 May 2021 06:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41519 |
Actions (login required)
 |
View Item |
