May, Arne and Goadsby, Peter J. (2001) Substance P receptor antagonists in the therapy of migraine. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 10 (4). pp. 673-678. ISSN 1354-3784
Full text not available from this repository.Abstract
Clinical observations, the vascular component of migraine pain, its pulsating or throbbing pain character, have focused attention on the trigeminal innervation of pain-sensitive intracranial structures, such as the dura mater and large vessels. These intracranial structures are innervated by the ophthalmic branch of the trigeminal nerve, which is marked by the presence of vasoactive peptides, such as substance P and caicitonin gene-related peptide. Substance P is a mediator of the sterile inflammation of the dura mater, which has been considered to be the source of migraine pain. Modem antimigraine drugs, such as 5-HT1B/D agonists (triptans), block this dural neurogenic inflammation dose-dependently in an animal model but their vasoconstrictor effects have led to a search for non-vasoconstrictor approaches. One such approach has been substance P (neurokinin-1) antagonists. These are highly effective in animal models of dural inflammation and have no significant vasoconstrictive effect. However, several NK1 antagonists failed to demonstrate any effect in acute migraine. Current clinical and experimental evidence therefore supports the view that NK1 receptor antagonists may have no significant antimigraine properties.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TACHYKININ NK1 RECEPTOR; NEUROGENIC PLASMA EXTRAVASATION; TRIGEMINAL NUCLEUS CAUDALIS; SUPERIOR SAGITTAL SINUS; GENE-RELATED PEPTIDE; RAT DURA-MATER; TRIGEMINOVASCULAR SYSTEM; EXTRACEREBRAL CIRCULATION; NEUROPEPTIDE CHANGES; ERGOT ALKALOIDS; migraine attack; neurogenic inflammation; plasma extravasation; substance P; trigeminovascular system |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 May 2021 06:24 |
| Last Modified: | 11 May 2021 06:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41535 |
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