Helfrich-Foerster, Charlotte and Winter, Christine and Hofbauer, Alois and Hall, Jeffrey C. and Stanewsky, Ralf (2001) The circadian clock of fruit flies is blind after elimination of all known photoreceptors. NEURON, 30 (1). pp. 249-261. ISSN 0896-6273
Full text not available from this repository. (Request a copy)Abstract
Circadian rhythms are entrained by light to follow the daily solar cycle. We show that Drosophila uses at least three light input pathways for this entrainment: (1) cryptochrome, acting in the pacemaker cells themselves, (2) the compound eyes, and (3) extraocular photoreception, possibly involving an internal structure known as the Hofbauer-Buchner eyelet, which is located underneath the compound eye and projects to the pacemaker center in the brain. Although influencing the circadian system in different ways, each input pathway appears capable of entraining circadian rhythms at the molecular and behavioral level. This entrainment is completely abolished in glass(60J) cry(b) double mutants, which lack all known external and internal eye structures in addition to being devoid of cryptochrome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIOD GENE-EXPRESSION; CENTRAL-NERVOUS-SYSTEM; DROSOPHILA-MELANOGASTER; ELECTROPHYSIOLOGICAL CHARACTERIZATION; DISCONNECTED MUTANTS; BEHAVIORAL RHYTHMS; TIMELESS GENES; LIGHT; CRYPTOCHROME; NEURONS; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Feb 2022 07:44 |
| Last Modified: | 08 Feb 2022 07:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41614 |
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