Zaak, Dirk and Kriegmair, Martin and Stepp, Herbert and Stepp, Helmut and Baumgartner, Reinhold and Oberneder, Ralph and Schneede, Peter and Corvin, Stefan and Frimberger, Dominic and Knuechel, Ruth and Hofstetter, Alfons (2001) Endoscopic detection of transitional cell carcinoma with 5-aminolevulinic acid: Results of 1012 fluorescence endoscopies. UROLOGY, 57 (4). pp. 690-694. ISSN 0090-4295, 1527-9995
Full text not available from this repository. (Request a copy)Abstract
Objectives. The initial encouraging results using 5-aminolevulinic acid (5-ALA) induced fluorescence endoscopy (AFE) have promised a procedure with an outstanding sensitivity for the detection of early stage bladder cancer. Summarized here is our clinical experience and data comprising 1012 fluorescence endoscopies. Methods. Two hours, 30 minutes before endoscopy, 1.5 g 5-ALA dissolved in 50 mL of 5.7% sodium monohydrogen phosphate was instilled in patients intravesically. Before AFE, all patients underwent white light endoscopy, and a bladder washing cytologic specimen was obtained. A special light source provided blue light (375 to 440 nm) for fluorescence excitation. Suspicious sites were identified by their red fluorescence contrasting against backscattered blue light when observed through the long pass filter (445 nm) integrated into the telescope eyepiece. Results. Two thousand four hundred seventy-five specimens were obtained (2.4 biopsies per AFE). In 552 AFEs (54.5%), neoplastic urothelial lesions were detected, in 34.2% only because of their positive fluorescence; 58.7% of these additionally detected neoplastic foci had poorly differentiated histologic features. Conclusions. AFE has proved to be a clinically feasible procedure with an outstanding detection rate for flat, urothelial, high-risk lesions. UROLOGY 57: 690-694, 2001. (C) 2001, Elsevier Science Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUPERFICIAL BLADDER-TUMORS; TRANSURETHRAL RESECTION; INTRAVESICAL INSTILLATION; UROTHELIAL CARCINOMA; PAPILLARY CARCINOMA; PROTOPORPHYRIN-IX; CANCER; RECURRENCE; BIOPSIES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Feb 2022 09:16 |
| Last Modified: | 08 Feb 2022 09:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41628 |
Actions (login required)
 |
View Item |
