Thewes, M. and Kretschmer, R. and Gfesser, M. and Rakoski, J. and Nerlich, M. and Borelli, S. and Ring, J. (2001) Immunohistochemical characterization of the perivascular infiltrate cells in tissues adjacent to stainless steel implants compared with titanium implants. ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 121 (4). pp. 223-226. ISSN 0936-8051
Full text not available from this repository.Abstract
Metallic orthopaedics implants are composed of elements that are known to be skin sensitizers in the general population In this study, we analyzed the cells of perivascular infiltration in the tissue adjacent to titanium (n = 23) and steel (n = 8) implants after explantation of the metals by immunohistochemical methods. The following panel of monoclonal antibodies were used as parameters: CD la (Langerhans cells), CD 4 (T-helper cells), CD 8 (T-suppressor cells), CD 11c (monocytes and macrophages), CD 45 RO (memory cells), CD 45 RA (naive cells), eosinophil cationic proteins (ECP), neutrophil elastase, and HLA-DR. The number of perivascular total cells did not differ significantly. All cells were identified in both metal subgroups, but a statistical difference was not seen in the above-mentioned parameters. We conclude that sensitization to metals is possible in the tissue adjacent to steel and titanium implants, because all cells which play an important role in allergic delayed-type hypersensitivity (type IV) reactions are present. This phenomenon may be called a 'pre-sensitization' phase, because no sensitization or allergic reactions were seen in our cases. Second, in the present study, a statistical difference was not seen in the number of infiltrate cells in the tissue adjacent to steel compared with titanium implants.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ALLERGY; immunohistochemistry; steel implant; titanium implant |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Feb 2022 06:20 |
| Last Modified: | 14 Feb 2022 06:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41679 |
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