Schmitz, Gerd and Kaminski, W. E. (2001) ABC transporters and cholesterol metabolism. FRONTIERS IN BIOSCIENCE, 6 (3). pp. 505-514. ISSN 1093-9946
Full text not available from this repository.Abstract
ATP-binding cassette (ABC) proteins form a group of highly conserved cellular transmembrane transporters. Studies over the past year have implicated ABC transporters in cellular lipid trafficking processes. This notion has recently been confirmed and extended by the finding that the ABC transporter ABCA1 is a key regulator of high-density lipoprotein (HDL) metabolism and macrophage targeting to the RES or the vascular wall. Expression of a large number of ABC transporters in monocytes/macrophages and their regulation by cholesterol flux render these transporter molecules potentially critical players in chronic inflammatory diseases such as atherosclerosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BINDING CASSETTE TRANSPORTER-1; MULTIDRUG-RESISTANCE PROTEIN; DISEASE GENE ABCR; FAMILIAL INTRAHEPATIC CHOLESTASIS; CAUSE PSEUDOXANTHOMA ELASTICUM; DUBIN-JOHNSON-SYNDROME; CONJUGATE EXPORT PUMP; MDR1 P-GLYCOPROTEIN; MAP KINASE CASCADE; RECEPTOR LXR-ALPHA; ABC transporter; ABCA1; macrophage; lipid; cholesterol; phospholipids; caveolin; NPC1; review |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 May 2021 07:55 |
| Last Modified: | 07 May 2021 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41694 |
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