Bischoff, Angela and Puettmann, Kristina and Koetting, Annette and Moser, Christiane and Buschauer, Armin and Michel, Martin C. (2001) Limited signal transduction repertoire of human Y-5 neuropeptide Y receptors expressed in HEC-1B cells. PEPTIDES, 22 (3). pp. 387-394. ISSN 0196-9781
Full text not available from this repository. (Request a copy)Abstract
In HEC-1B cells transfected with human Y-5 neuropeptide Y (NPY) receptors (but not in non-transfected cells) NPY inhibited forskolin-stimulated cAMP accumulation in a pertussis toxin-sensitive manner (-log EC50 8.88 +/- 0.25). Elevations of intracellular Ca2+ were largely restricted to very high NPY concentrations and similar in transfected and nontransfected cells. NPY did not increase inositol phosphate accumulation and did not activate a variety of isoforms of protein kinase C or mitogen-activated protein kinases. We conclude that at least upon expression in HEC-1B cells the signal transduction of Y-5 NPY receptors is limited to inhibition of cAMP accumulation. (C) 2001 Elsevier Science Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SMOOTH-MUSCLE CELLS; PROTEIN-KINASE-C; HUMAN ERYTHROLEUKEMIA-CELLS; INOSITOL PHOSPHOLIPID HYDROLYSIS; PERITONEAL MAST-CELLS; N-MC CELLS; PEPTIDE-YY; INTRACELLULAR CA2+; PANCREATIC-POLYPEPTIDE; FUNCTIONAL EXPRESSION; G-protein; adenylyl cyclase; phospholipase C; calcium; protein kinase C; mitogen-activated protein kinase |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Feb 2022 16:24 |
| Last Modified: | 14 Feb 2022 16:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41721 |
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