Kaminski, Wolfgang E. and Piehler, Armin and Puellmann, Kerstin and Porsch-Özcürümez, Mustafa and Duong, Chinh and Bared, Guido Maa and Buechler, Christa and Schmitz, Gerd (2001) Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 281 (1). pp. 249-258. ISSN 0006-291X
Full text not available from this repository. (Request a copy)Abstract
Members of the human ABC transporter A subfamily have gained considerable attention based on the recent findings that ABCA1 and ABCR (ABCA4) cause familial HDL-deficiency syndromes and distinct forms of hereditary retinopathies, respectively. Here we report the complete cDNA and the genomic organization of ABCA2, another member of the human ABC A transporter subfamily. The ABCA2 coding region is 7.3 kb in size and codes for a 2436 amino acid polypeptide that bears the typical features of a full-size ABC transporter. Among the known members of the ABC A subfamily ABCA2 shares highest homology with the cholesterol-responsive transporters ABCA1 (50%) and the recently cloned ABCA7 (44%). The ABCA2 gene comprises 48 exons which are localized within a genomic region of only 21 kb. Analysis of the putative ABCA2 promoter sequence revealed potential binding sites for transcription factors that are involved in the differentiation of myeloid and neural cells. Gene expression analysis in human macrophages showed that ABCA2 mRNA is induced during cholesterol import indicating that ABCA2 is a cholesterol-responsive gene. Our results suggest a potential role for ABCA2 in macrophage lipid metabolism and neural development. (C) 2001 Academic Press.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATP-BINDING CASSETTE; TANGIER-DISEASE; TRANSCRIPTION FACTORS; MOLECULAR-CLONING; TRANSPORTER ABCA7; FACTOR-I; IDENTIFICATION; ORGANIZATION; EXPRESSION; MUTATIONS; |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 06:17 |
| Last Modified: | 15 Feb 2022 06:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41746 |
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