Brandl, Friedrich and Pustet, Nikola and Mannschreck, Albrecht (2001) Chiroptical detection during liquid chromatography 7 - The rotation angle/absorbance ratio of chiral molecules. Its possible use for on-line analysis during preparative separations of enantiomers. JOURNAL OF CHROMATOGRAPHY A, 909 (2). pp. 147-154. ISSN 0021-9673
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The rotation angle/absorbance ratios C(+) = alpha (+)/A(+) and C(-) = alpha (-)/A(-), determined via,detection by a polarimeter and a photometer, were checked for the first time with reference to their use for on-line analysis during preparative separations. For this purpose, (+)-, (-)- and (+/-)-carvones were investigated by liquid chromatography (LC) on microcrystalline tribenzoylcelulose. It turned out that the ratios C(+) and C(-) depend only slightly upon concentration (Table I). Overlapped peaks of enantiomers were successfully submitted to computer deconvolution (e.g. Pig. 2, bottom). A procedure for on-line analysis during preparative LC is proposed. (C) 2001 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIRCULAR-DICHROISM; POLARIMETRIC DETECTION; PURITY; TRIACETYLCELLULOSE; QUANTITATION; SORBENT; EXCESS; SPITE; HPLC; enantiomer separation; preparative chromatography; detection; LC; polarimetric detection; carvone |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Prof.Dr. Mannschreck |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 06:20 |
| Last Modified: | 15 Feb 2022 06:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41748 |
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