Kaesbauer, Christian W. and Paper, Dietrich H. and Franz, Gerhard (2001) Sulfated beta-(1 -> 4)-galacto-oligosaccharides and their effect on angiogenesis. CARBOHYDRATE RESEARCH, 330 (3). pp. 427-430. ISSN 0008-6215, 1873-426X
Full text not available from this repository. (Request a copy)Abstract
Sulfated beta-(1 --> 4)-galacto-oligosaccharides were prepared from an arabino-galacto-rhamno-galacturonan from Lupinus polyphyllus Lindl. by successive partial hydrolysis and SO3-pyridine sulfation in DMF. The resulting oligosaccharide polysulfates were analyzed by analytical GPC and the sulfate content was determined by ion chromatography. DP 5 and higher showed a pronounced antiangiogenic effect with scores of 0.9-1.2 for DP 7-9 using the CAM-assay. An interaction with the fibroblast growth factor FGF-2 was noticed for DP 4-12 depending on the degree of sulfation using the FGF-2-trypsin assay. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FIBROBLAST GROWTH-FACTOR; HEPARIN; INHIBITORS; angiogenesis inhibitor; CAM-assay; FGF-2; galactan; sulfated galacto-oligosaccharides |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 06:40 |
| Last Modified: | 15 Feb 2022 06:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41751 |
Actions (login required)
 |
View Item |
