Blumberg, Friedrich C. and Wolf, K. and Sandner, P. and Lorenz, C. and Riegger, Guenter A. J. and Pfeifer, M. (2001) The NO donor molsidomine reduces endothelin-1 gene expression in chronic hypoxic rat lungs. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 280 (2). L258-L263. ISSN 1040-0605, 1522-1504
Full text not available from this repository. (Request a copy)Abstract
We investigated the effects of the nitric oxide (NO) donor molsidomine and the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME) on pulmonary endothelin (ET)-1 gene expression and ET-1 plasma levels in chronic hypoxic rats. Two and four weeks of hypoxia (10% O-2) significantly increased right ventricular systolic pressure, the medial cross-sectional vascular wall area of the pulmonary arteries, and pulmonary ET-1 mRNA expression (2-fold and 3.2-fold, respectively). ET-1 plasma levels were elevated after 4 wk of hypoxia. In rats exposed to 4 wk of hypoxia, molsidomine (15 mg.kg(-1).day(-1)) given either from the beginning or after 2 wk of hypoxia significantly reduced pulmonary hypertension, pulmonary vascular remodeling, pulmonary ET-1 gene expression, and ET-1 plasma levels. L-NAME administration (45 mg.kg(-1).day(-1)) in rats subjected to 2 wk of hypoxia did not modify these parameters. Our findings suggest that in chronic hypoxic rats, exogenously administered NO acts in part by suppressing the formation of ET-1. In contrast, inhibition of endogenous NO production exerts only minor effects on the pulmonary circulation and pulmonary ET-1 synthesis in these animals.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCED PULMONARY-HYPERTENSION; SMOOTH-MUSCLE CELLS; NITRIC-OXIDE; L-ARGININE; VASCULAR ENDOTHELIUM; INHIBITION; VASODILATION; INHALATION; PEPTIDE; pulmonary hypertension; chronic hypoxia; nitric oxide |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 07:11 |
| Last Modified: | 15 Feb 2022 07:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41757 |
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