Hansen, Ernil and Bucher, Michael and Jakob, Wolfgang and Lemberger, Peter and Kees, Frieder (2001) Pharmacokinetics of levofloxacin during continuous veno-venous hemofiltration. INTENSIVE CARE MEDICINE, 27 (2). pp. 371-375. ISSN 0342-4642
Full text not available from this repository. (Request a copy)Abstract
Objective: To study the effect of continuous veno-venous hemofiltration (CVVHF) on the pharmacokinetics of levofloxacin in critically ill patients with acute renal failure. Design: Open-label study. Setting: Anesthesiology ICU, University Hospital of Regensburg. Patients: Six critically ill patients treated with CVVHF because of acute renal failure needing antimicrobial therapy. Interventions: Levofloxacin i. v. 250 mg qd with a starting dose of 500 mg. CVVHF with the following characteristics: hemofilter AN69 hollow fibers of 0.90 m(2) area, blood flow 150 ml/min, ultrafiltrate flow 1.3 l/h, filtrate substitution in post-dilution mode. Measurements and results: The plasma pharmacokinetics and clearance of levofloxacin by hemofiltration were established on day 1 and day 4-6 of treatment. Levofloxacin was determined by high-performance liquid chromatography (HPLC). Mean (range) peak plasma concentrations after levofloxacin 500 mg single dose (s.d.) and 250 mg multiple dose (m.d.) were 6.4 (2.7-9.3) and 8.2 (4.7-10.3) mg/l, trough levels 2.7 (1.4-5.0) and 2.9 (1.7-3.9) mg/l, half-life 28 (19-38) and 22 (17-31) h, volume of distribution 1.2 (0.72-1.6) l/kg and 0.91 (0.52-2.0) l/kg, respectively. The mean sieving coefficient was 0.96 (0.79-1.09), mean total clearance 47 (20-89) ml/min, and mean clearance by hemofiltration 21 (13-27) ml/min, respectively. Conclusion: A dosage schedule of levofloxacin 250 mg qd with a 500 mg loading dose seems appropriate for anuric patients during CVVHF. Sufficiently high steadystate concentrations of levofloxacin were achieved after the first dose. Undesired accumulation of levofloxacin was not observed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTINUOUS VENOVENOUS HEMOFILTRATION; RENAL REPLACEMENT THERAPY; CRITICALLY ILL PATIENTS; CLINICAL PHARMACOKINETICS; levofloxacin; pharmacokinetics; renal failure; continuous veno-venous hemofiltration |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 09:30 |
| Last Modified: | 15 Feb 2022 09:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41773 |
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