Scheurlen, Wolfram and Ramasubbu, Kumudha and Wachowski, Olga and Hemauer, Andrea and Modrow, Susanne (2001) Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection. JOURNAL OF CLINICAL VIROLOGY, 20 (3). pp. 173-178. ISSN 1386-6532
Full text not available from this repository. (Request a copy)Abstract
Objective: We report an Ii-year-old boy presenting with splenomegaly, chronic thrombocytopenia and concordant neutropenia. Results: In contrast to autoantibodies against platelets, there were no detectable neutrophil-specific autoantibodies present in this patient. Extensive serologic investigations revealed increased IgM- and IgG-antibody titers against parvovirus B19. A nested polymerase chain reaction (PCR) showed parvovirus B19-specific sequences in the patient's bone-marrow cells but not in the serum. Specific antibodies against the structural proteins VP1 and VP2 in addition to those against non-structural protein NS1 of parvovirus B19 were detected by Western blot analysis. Thrombocytopenia and neutropenia responded to immunosuppressive therapy and subsequent splenectomy, the latter being necessary due to severe side-effects of steroid medication. Conclusion: Autoimmune thrombocytopenia/neutropenia may have been triggered and/or sustained by a chronic parvovirus B19 infection. Patients with this very rare disorder should be screened for this virus. (C) 2001 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | B19-ASSOCIATED HEMOPHAGOCYTIC SYNDROME; IDIOPATHIC THROMBOCYTOPENIC PURPURA; NONSTRUCTURAL PROTEIN; NEUTROPENIA; ANTIBODIES; VIRUS; CHILDHOOD; CHILDREN; THERAPY; DISEASE; chronic autoimmune neutropenia/thrombocytopenia; parvovirus B19 infection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 09:56 |
| Last Modified: | 15 Feb 2022 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41777 |
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