Schneider, Annette and Greene, Richard E. and Keyl, Cornelius and Bandinelli, Gabriele and Passino, Claudio and Spadacini, Giammario and Bonfichi, Maurizio and Arcaini, Luca and Malcovati, Luca and Boiardi, Amerigo and Feil, Paul and Bernardi, Luciano (2001) Peripheral arterial vascular function at altitude: sea-level natives versus Himalayan high-altitude natives. JOURNAL OF HYPERTENSION, 19 (2). pp. 213-222. ISSN 0263-6352
Full text not available from this repository.Abstract
Objectives Regulation of the vascular system may limit physical performance and contribute to adaptation to high altitude. We evaluated vascular function in 10 Himalayan high-altitude natives and 10 recently acclimatized sea-level natives at an altitude of 5050 m. Methods We registered electrocardiogram, blood flow velocity in the common femoral artery, and blood pressure in the radial artery using non-invasive methods under baseline conditions, and during maximal vasodilation after 2 min leg occlusion, Vascular mechanics were characterized by estimating pulse wave Velocity and input impedance. Results Pulse wave velocity and parameters of input impedance did not differ between groups under baseline conditions. In the post-ischemic period, the ratio between maximal hyperemic and baseline blood flow velocity was significantly higher in the high-altitude than in the sea-level natives (5.7 +/- 2.5 versus 3.8 +/- 1.2, P < 0.05). The leg vascular resistance decreased in the post-occlusive period without differences between groups. Characteristic impedance decreased in the post-ischemic period by about one third of the baseline level without differences between groups. The post-ischemic decrease of input impedance modulus was more marked in the high-attitude than in the sea-level natives at low frequencies (28 +/- 12 versus 6.4 +/- 20% at 2 Hz, P < 0.01). Conclusions Our results demonstrate a superior ability to increase blood flow velocity as a response to muscular ischemia in high-altitude natives compared to sea-level natives. This phenomenon may be associated with a more effective coupling between blood pressure and blood flow which is probably caused by differences in conduit vessel function. (C) 2001 Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC HEART-FAILURE; OPERATION EVEREST-II; REACTIVE HYPEREMIA; EXERCISE PERFORMANCE; SKELETAL-MUSCLE; BLOOD-PRESSURE; IMPEDANCE; FLOW; HEMODYNAMICS; CONDUCTANCE; arteries; blood flow; hypoxia; vasodilation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 10:02 |
| Last Modified: | 15 Feb 2022 10:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41779 |
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