Barlage, S. and Froehlich, D. and Boettcher, A. and Jauhiainen, M. and Mueller, H. P. and Noetzel, F. and Rothe, G. and Schuett, C. and Linke, R. P. and Lackner, K. J. and Ehnholm, C. and Schmitz, Gerd (2001) ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response. JOURNAL OF LIPID RESEARCH, 42 (2). pp. 281-290. ISSN 0022-2275
Full text not available from this repository. (Request a copy)Abstract
High density lipoproteins (HDL) mediate reverse cholesterol transport as well as the clearance of oxidation products or inflammatory mediators, thereby contributing to tissue integrity. The decrease in HDL in inflammation has been attributed to decreased lecithin:cholesterol acyltransferase activity, whereas the role of phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein has not been analyzed in detail. We have studied the activities of HDL-modifying proteins and the heterogeneity of HDL in healthy control subjects and three groups of postsurgery patients: no bacterial infection (group I), bacterial focus and systemic inflammatory response (group 2), and severe sepsis (group 3), For all patients, a decrease in total HDL could be demonstrated, with a loss of mainly large, apolipoprotein A-I (apoA-I) HDL particles, an almost total loss of apoC-I, and an increase in apoE HDL (200-500 kDa), which did not contain significant amounts of apoA-I, apoA-II, or apoC-I, PLTP activity was increased in patients of groups 2 and 3, paralleled by a redistribution of PLTP into a population of small (120- to 200-kDa) particles, probably representing PLTP homodimers or lipid-complexed PLTP. In summary, the increase in apoE HDL and PLTP activity may improve the delivery of energy substrates and phospholipids to tissues that must maintain cellular membrane homeostasis under conditions of inflammatory stress.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | APOLIPOPROTEIN-A-I; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; LIPOPOLYSACCHARIDE-BINDING PROTEIN; ESTER TRANSFER PROTEIN; HUMAN PLASMA; BLOOD-PLASMA; ISOTACHOPHORESIS; SPHINGOMYELIN; ENDOTOXEMIA; ANTIBODIES; cholesteryl ester transfer protein; lipopolysaccharide-binding protein; inflammation; sepsis; isotachophoresis; apolipoprotein E |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 10:19 |
| Last Modified: | 15 Feb 2022 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41782 |
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