Kanzok, Stafan M. and Fechner, Anke and Bauer, Holger and Ulschmid, Julia K. and Mueller, Hans-Michael and Botella-Munoz, Jose and Schneuwly, Stephan and Schirmer, Rolf Heiner and Becker, Katja (2001) Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. SCIENCE, 291 (5504). pp. 643-646. ISSN 0036-8075
Full text not available from this repository. (Request a copy)Abstract
The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage. Here we demonstrate the absence of glutathione reductase in Drosophila melanogaster, identify a new type of thioredoxin reductase, and provide evidence that a thioredoxin system supports GSSG reduction. Our data suggest that antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN PLACENTA; GENE; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2022 14:09 |
| Last Modified: | 15 Feb 2022 14:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41804 |
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