Mueller, Klaus and Reindl, Hans and Breu, Klaus (2001) Heterocyclic substituted anthralin derivatives as inhibitors of keratinocyte growth and inducers of differentiation. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11 (1). pp. 47-50. ISSN 0960-894X
Full text not available from this repository. (Request a copy)Abstract
Heterocyclic substituted derivatives of the antipsoriatic anthralin were synthesized and evaluated in vitro for their antiproliferative action against keratinocytes and their ability to induce keratinocyte differentiation. The indole-2-carboxylic acid analogue 2e exhibited the same excellent antiproliferative activity as anthralin and also induced terminal differentiation of keratinocytes. As a benefit of its strongly diminished potential to generate oxygen radicals, 2e did not induce damage of keratinocyte membranes. (C) 2000 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MODULATED REDOX PROPERTIES; ANTIPSORIATIC ANTHRONES; PROTEIN; 1,8-DIHYDROXY-9(10H)-ANTHRACENONES; 5-LIPOXYGENASE; QUANTITATION; DITHRANOL; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2022 07:57 |
| Last Modified: | 22 Feb 2022 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41812 |
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