Wiesner, Gunther and Hoerauf, Klaus and Schroegendorfer, Klaus and Sobczynski, Pawel and Harth, Marion and Ruediger, Hugo W. (2001) High-level, but not low-level, occupational exposure to inhaled anesthetics is associated with genotoxicity in the micronucleus assay. ANESTHESIA AND ANALGESIA, 92 (1). pp. 118-122. ISSN 0003-2999
Full text not available from this repository. (Request a copy)Abstract
To minimize the possible health risks posed by waste anesthetic gases, the National Institute of Occupational Safety and Health (NIOSH) recommends exposure limits. We investigated the genotoxicity of a previously established occupational exposure exceeding these Limits (high-level exposure) and of one within these limits (low-level exposure). Genotoxicity was assessed by the formation of micronucleated lymphocytes in 25 anesthetists and anesthetic nurses of an Eastern European (High-Level Exposure Group) and a German (Low-Level Exposure Group) university hospital. Each exposed group was compared with a group of nonexposed personnel of the same hospital. Compared with its Control Group, there was an increased fraction of micronucleated lymphocytes per 1000 binucleated cells in the High-Level Exposure Group (median 14.0, range 9.0-26.7 vs median 11.3, range 3.2-19.4; P < 0.05) but not in the Low-Level Exposure Group (median 9.8, range 4.2-20.0 vs median 10.5, range 5.0-20.5). We conclude that a high-level exposure to inhaled anesthetics is associated with an increase in chromosome damage, and measures are recommended to decrease exposure levels. As evidenced by the formation of micronucleated lymphocytes, the threshold values recommended by NIOSH appear to be safe.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPERATING-ROOM PERSONNEL; SISTER-CHROMATID EXCHANGES; NITROUS-OXIDE; DENTAL ASSISTANTS; HUMAN-POPULATIONS; LYMPHOCYTES; CANCER; DAMAGE; GASES; ABERRATIONS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2022 10:00 |
| Last Modified: | 22 Feb 2022 10:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41819 |
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