Karrer, Sigrid and Eholzer, Christian and Ackermann, Guenther and Landthaler, Michael and Szeimies, Rolf-Markus (2001) Phototherapy of psoriasis: Comparative experience of different phototherapeutic approaches. DERMATOLOGY, 202 (2). pp. 108-115. ISSN 1018-8665, 1421-9832
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Background: Broad-band UVB alone or in combination with different topical drugs (anthralin, calcipotriol), systemic PUVA and bath-PUVA therapy are very effective and well-established treatment modalities for psoriasis. Objective: The aim of this retrospective study was to assess which of these routinely applied phototherapeutic modalities might be most effective and safe for the treatment of plaque-type psoriasis. Methods: Patients (n = 203) with moderate to severe (pretreatment Psoriasis Area and Severity Index score between 12 and 35) chronic plaque-type psoriasis treated between 1992 and 1998 at our department with either UVB (with/without anthralin or calcipotriol; n = 97), systemic PUVA (n = 19) or bath-PUVA therapy (n = 87) were evaluated for efficacy, duration of treatment, number of treatments necessary for complete remission (CR), cumulative light dose, side effects of therapy and duration of remission after therapy. Results: No statistically significant difference comparing the efficacy of bath-PUVA (CR in 72.4%), PUVA (CR in 89.5%) and UVB phototherapy (CR in 69.1%) was found. Although the duration of therapy was significantly longer for bath-PUVA (66 +/- 42 days) as compared to UVB treatment (50 +/- 27 days), the mean number of treatments did not differ significantly be-tween bath-PUVA (28 +/- 12), UVB therapy(30 +/- 12) and PUVA(26 +/- 13). Significantly fewer side effects of phototherapy were observed with bath-PUVA (14.9%) therapy compared to UVB treatment (30.9%). Also, the duration of remission after successful therapy was significantly longer for bath-PUVA (8.4 +/- 3.5 months) as compared to UVB phototherapy(5.1 +/- 4.2 months). Conclusion: Bath-PUVA therapy has some advantages over UVB phototherapy in the treatment of psoriasis: fewer UV-related acute side effects and a longer period of remission after therapy. However, the choice of treatment with either UVB, bath-PUVA or systemic PUVA should also be based on a history of previous response to treatment and patient considerations, including compliance and responsibility for following the precautions to avoid potential side effects. Copyright (C) 2001 S. Karger AG. Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BATH-WATER DELIVERY; PUVA THERAPY; CALCIPOTRIOL MC-903; CARCINOGENIC RISK; PLUS UVA; PHOTOCHEMOTHERAPY; 8-METHOXYPSORALEN; PSORALENS; SKIN; COMBINATION; psoriasis; UVB; PUVA; bath-PUVA; side effects |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2022 07:51 |
| Last Modified: | 28 Feb 2022 07:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41850 |
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