Muders, Frank and Neubauer, Stefan and Luchner, Andreas and Fredersdorf, Sabine and Ickenstein, Guntram and Riegger, Guenter A. J. and Horn, Michael and Elsner, Dietmar (2001) Alterations in myocardial creatinine kinase (CK) and lactate dehydrogenase (LDH) isoenzyme-distribution in a model of left ventricular dysfunction. EUROPEAN JOURNAL OF HEART FAILURE, 3 (1). pp. 1-5. ISSN 1388-9842
Full text not available from this repository.Abstract
The purpose of the current study was to evaluate myocardial creatinine kinase (CK) and lactate dehydrogenase (LDH) systems in a model of epinephrine-induced cardiomyopathy in rabbits. Eight rabbits received four repetitive epinephrine infusions (300 mg/kg/60 min, i.v.) in 12-day intervals and eight untreated rabbits served as controls (CTRL). Echocardiography demonstrated a significant deterioration of LV function as well as increased LV-diameter and -mass index in catecholamine-induced cardiomyopathy. Histological examination revealed that repetitive catecholamine infusion resulted in LV fibrous areas with collagenous content and an increase in myocyte width (16.9 +/- 0.8 mum vs. CTRL 12.9 +/- 0.9; P < 0.05). LV dysfunction was associated with a decreased total LV lactate dehydrogenase activity (LDH; 0.43 +/- 0.03 IU/mg protein vs. CTRL 0.52 +/- 0.04; P < 0.05) whereas total creatinine kinase activity was unchanged (CK; 7.30 +/- 0.63 IU/mg protein vs. CTRL 9.20 +/- 0.49, n.s.). Furthermore, myocardial LDH isoenzymes were shifted with a decrease in LDH, and an increase in LDH, and LDH, (LDH,: 84.90 +/- 2.60% vs. CTRL 94.50 +/- 0.40; LDH2: 7.30 +/- 1.20% vs. 1.50 +/- 0.13; LDH3: 5.40 +/- 0.90% vs. 3.20 +/- 0.25; all P < 0.05). Foetal B-CK isoenzymes were significantly increased (CK-MB 5.30 +/- 0.66 vs. 2.20 +/- 0.35%; P < 0.05). The current study demonstrates changes in cardiac energy metabolism including an impaired LDH activity with a shift towards anaerobic isoenzymes as well as a more efficient CK system in a model of catecholamine-induced LV dysfunction. (C) 2001 European Society of Cardiology. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENERGY-METABOLISM; RAT HEARTS; SYSTEM; CARDIOMYOPATHY; INFARCTION; FAILURE; myocardium; creatinine kinase; lactate dehydrogenase; isoenzymes; LV dysfunction |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2022 08:00 |
| Last Modified: | 28 Feb 2022 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41853 |
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