Zietz, B. and Hrach, S. and Schoelmerich, Juergen and Straub, Rainer H. (2001) Differential age-related changes of hypothalamus pituitary adrenal axis hormones in healthy women and men - Role of interleukin 6. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 109 (2). pp. 93-101. ISSN 0947-7349, 1439-3646
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Aging is accompanied by marked changes of steroid hormone levels which vary among women and men. The age-related increase of cytokines such as interleukin (IL)- 6 may modulate the endocrine system. We aimed to investigate the role of IL-6 for the gender-specific changes of acrophase steroid hormone secretion in healthy subjects during aging. Out of 120 healthy subjects, 60 men and 48 women (non luteal phase) were recruited (age: 18 to 75 years). Age was positively correlated with IL-6 (female and male: p<0.001) and adrenocorticotropic hormone (ACTH) in women only (p<0.001). Age was negatively correlated with progesterone (female and male: p<0.001), cortisol (only female: p=0.003), androstenedione (female and male: p<0.001), but not 17OH progesterone. After correction for IL-6, the age related decrease of steroid hormones was blunted in both gender groups except for androstenedione (female and male: p<0.005). Furthermore, the ratio of serum cortisol to plasma ACTH decreased with age only in women but not in men (female: pi 0.001). Correction for IL 6 did not markedly change the negative interrelationship between age and the mentioned ratio in these women. However, a linear regression analysis revealed that the increase of ACTH in relation to cortisol depends on serum free testosterone in men (p=0.042) End on serum free 17<beta>-estradiol (p<0.001) together with serum IL-6 in women (p=0.021). In conclusion, IL-6 plays an important role for acrophase pituitary and peripheral hormone secretion in women only. The gender-specific changes of cortisol in relation to ACTH depend on the age-related decrease of the respective sex hormone in both gender groups and the increase of IL-6 in women. This study underlines the hormone-like role of IL-6 in the aging process of the endocrine system in women.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; RECOMBINANT HUMAN INTERLEUKIN-6; POSTMENOPAUSAL WOMEN; ADRENOCORTICAL AXIS; SERUM INTERLEUKIN-6; CYTOKINE PRODUCTION; CORTISOL SECRETION; MONONUCLEAR-CELLS; FACTOR-ALPHA; BONE-MARROW; IL-6; aging; hypothalamic-pituitary-adrenal axis; steroid hormones |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2022 08:07 |
| Last Modified: | 28 Feb 2022 08:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41855 |
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